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Wilms Tumor Ppt New Review

Your new PPT must clearly contrast these two philosophies:

| Feature | COG (North America) | SIOP (Europe & most of world) | |--------|---------------------|-------------------------------| | Initial step | Immediate nephrectomy | Preoperative chemotherapy (4 weeks) | | Stage definition | Based on surgical/pathologic findings | Based on imaging response & post-chemo histology | | Advantage | Precise surgical staging | Reduced rupture rate, lower stage distribution | | Disadvantage | Higher surgical complications | Risk of treating non-Wilms tumors (very low) | wilms tumor ppt new

New consensus: Increasing cross-continental harmonization. The new UMBRELLA protocol (2019-ongoing) integrates molecular risk factors from both systems. Your new PPT must clearly contrast these two

  • Staging systems:
  • Biopsy:

    • Subtitle: A Modern Slide Deck for Pediatric Oncology, Nephrology, and Radiology Teams Staging systems:

    | Stage | Description | |-------|-------------| | I | Tumor limited to kidney, completely resected, capsule intact. | | II | Tumor extends beyond kidney but completely resected (no residual). | | III | Residual non-hematogenous tumor post-op (e.g., positive margins, lymph node involvement). | | IV | Hematogenous metastases (lung, liver, bone, brain). | | V | Bilateral renal involvement at diagnosis. |