There Was An Unhandled Exception Trying To Save Your Rom To Disk -

Permission issues can be bypassed by elevating privileges:

If the error disappears, you have a permanent permissions problem. The better fix is to move your ROMs and saves to a non-protected folder (e.g., C:\Users\YourName\Emulation\). Permission issues can be bypassed by elevating privileges:

Portable versions run entirely from one folder without writing to system locations.
Example: RetroArch Portable for Windows. Extract to a folder like D:\RetroArch, and all saves stay inside that folder. If the error disappears, you have a permanent

Often, the solution is embarrassingly simple. Perform these five checks before diving into complex settings. If the error disappears