Assumption: You have a legal emulator archive without copyrighted game/BIOS files included.
Extract
Inspect files
First run (recommended: as non-admin user)
Configure basic folders
Controller setup
Graphics & performance
Audio
BIOS files (legal owners only)
Loading a game (legal owners only)
Save & configuration backup
Go to Config > Video > Renderer. Switch from Vulkan to Software mode. Launch the game, then switch back to Vulkan. This forces the exclusive frame-buffer to reset.
To set up PCSX2, follow these basic steps. Note that these steps are generalized and based on the assumption that you're using a relatively recent version of PCSX2: pcsx510r1setupzip exclusive
Initial Setup:
BIOS:
Play a Game: