If you know your way around Windows Device Manager:
Warning: This can break other Apple services. A full iTunes downgrade is safer.
Restart your PC.
Download iTunes 11.1.5 (64-bit or 32-bit) from a trusted archive like oldversion.com or filehippo.com. p0sixspwn requires itunes 105 or above
Install iTunes 11.1.5 and do NOT let it auto-update.
Block Apple software updates by renaming AppleSoftwareUpdate.exe (found in C:\Program Files\Common Files\Apple\Apple Software Update).
Run p0sixspwn as Administrator – the error should disappear. If you know your way around Windows Device Manager:
iTunes from the Microsoft Store is not recommended – it lacks necessary drivers. Use the classic iTunes installer from Apple’s website (version 11.4 or 12.6.5 is a safe bet).
If you want to keep a newer iTunes but fool p0sixspwn:
Between iTunes 10.5 (released in October 2011) and iTunes 11/12, Apple made significant changes to the AppleMobileDeviceSupport architecture. p0sixspwn was compiled using API calls and communication protocols that were standard in the iTunes 10.5 era. Warning: This can break other Apple services
When you run p0sixspwn on a modern system with iTunes 12 or higher, the underlying driver version is too new. The jailbreak tool sends a command expecting a specific response structure from iTunes 10.5’s driver—but the newer driver returns data in a different format or rejects certain legacy calls.
If you can’t or don’t want to downgrade your main system’s iTunes, virtualization is your friend.
Before tackling the error, let’s understand the tool itself.
p0sixspwn works by exploiting a vulnerability in the way iOS 6 handles certain system calls. However, to communicate with the iDevice, the tool relies entirely on Apple’s mobile device drivers—which are bundled with iTunes.